Services available for Texas A&M University researches
What is an AUP Search?
All vertebrate animals must be covered by an Animal Use Protocol (AUP) approved by the Institutional Animal Care and Use Committee (IACUC) prior to acquisition and/or use of animals and throughout the entire period of animal use or maintenance.
What should be considered for an AUP search?
A search for alternatives to animal use includes searching for 3 R's, as described by Russell and Birch (1959) The Principles of Human Experimental Technique
- refinement: examples of refinements of the protocol include use of analgesics, remote telemetry to increase quality/quantity of data gathered, human endpoints for animals
- reducation: use of shared control groups, preliminary screening in non-animal systems, innovative statistical packages or consult a statistician
- replacement: alternatives to animal use- in vitro, cell culture, tissue culture, models, simulations, also use of non-mammals, fish, or invertebrates
The Medical Sciences Library will provide support to researchers at Texas A&M University by conducting searches for alternatives to Animal Use Protocols. After receiving the form,
- librarian will contact you to complete the reference interview and negotiate timeline for completing the search
- researcher will receive a description of all searches and list of related citations
More resources on AUP Searches
- TAMU, Research Compliance & Biosafety, Animal Use Protocol
- Alternatives to Animal Testing on the Web (ALTWEB)
- Animal Welfare Information Center (AWIC) from National Agricultureal Library
- Center for Alternative to Animal Testing (Johns Hopkins University)
- Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) U. S. Department of Health &Human Services
- Model Organisms for Biomedical Research from National Institutes of Health
- Three R's Microsite from CCAC